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Objective To investigate the predictive value of protein C( PC) for long -term mortality of patients with community-acquired pneumonia(CAP).Methods A total of 657 patients with CAP were enrolled in Taian Central Hospital from January 2011 to December 2011.The patients were divided into short-term group(≤30 days),medium-term group(>30~90 days) and long-term group(>90 days).PC,high sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),pneumonia severity index(PSI) score and CURB-65 score were measured at the time of admission.The ROC curve was used to evaluate the independent risk factors.The Kaplan-Meier surviv-al function curve was used to analyze the difference of mortality between the short-term group and long-term group. Independent risk factors for CAP risk were analyzed by COX regression.Results A total of 597 cases were followed up,there were 49 cases(8.09% ) in the short-term group,11 cases(1.84% ) in the medium -term group,and 537 cases(89.93% ) in the long-term group.The PC levels in the short-term group,medium-term group and long-term group were (32.2 ± 10.6)% ,(43.1 ± 9.9)% ,(69.6 ± 23.0)% ,respectively.The level of PC was signifi-cantly increased in the short-term group compared with the medium-term group and long-term group ( short-term group vs.medium-term group,q =6.18,P <0.05,short -term group vs.long -term group,q=9.87,P <0.05).The hs-CRP levels in the short-term group,medium-term group and long-term group were (108.1 ± 22.4)mg/L,(68.2 ± 12.9 ) mg/L, ( 25.1 ± 17.1 ) mg/L, respectively. The level of hs - CRP was significantly increased in the short-term group compared with the medium-term group and long-term group (short-term group vs.medium-term group, q =5.23, P <0.05, short -term group vs. long -term group, q =12.95, P<0.05 ). Meanwhile,PC showed higher accuracy(AUC,0.889) than CURB-65( AUC,0.828) and hs-CRP( AUC,0.711) in the long-term group.The Kaplan-Meier survival function curve showed that the mortality rate was significantly higher in the high-value group compared with the low-value group(F=17.10,P<0.01).PC was an independent factor for long - term mortality and was associated with poorer survival by the COX regression analysis. Conclusion PC has a high predictive value for long-term mortality in CAP patients.
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Oncolytic viruses have made great breakthroughs in cancer treatment, especially for reovirus, which can effectively induce the death of tumor cells without harming the normal tissues. More than 80％ tumor cells are sensitive to reovirus infection. Reovirus induces the apoptosis of tumor cells and exerts anti-tumor immunity to achieve anti-tumor activity, and the curative effect of combination therapy with reovirus and chemotherapeutic drugs exceeds the effect of monotherapy. Reovirus can exert anti-tumor effects through different mechanisms, which is of great significance for the new and effective treatment of tumors in the future.
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Objective@#To investigate the predictive value of protein C(PC) for long-term mortality of patients with community-acquired pneumonia(CAP).@*Methods@#A total of 657 patients with CAP were enrolled in Taian Central Hospital from January 2011 to December 2011.The patients were divided into short-term group(≤30 days), medium-term group(>30~90 days) and long-term group(>90 days). PC, high sensitivity C-reactive protein(hs-CRP), procalcitonin(PCT), pneumonia severity index(PSI) score and CURB-65 score were measured at the time of admission.The ROC curve was used to evaluate the independent risk factors.The Kaplan-Meier survival function curve was used to analyze the difference of mortality between the short-term group and long-term group.Independent risk factors for CAP risk were analyzed by COX regression.@*Results@#A total of 597 cases were followed up, there were 49 cases(8.09%) in the short-term group, 11 cases(1.84%) in the medium-term group, and 537 cases(89.93%) in the long-term group.The PC levels in the short-term group, medium-term group and long-term group were (32.2±10.6)%, (43.1±9.9)%, (69.6±23.0)%, respectively.The level of PC was significantly increased in the short-term group compared with the medium-term group and long-term group (short-term group vs.medium-term group, q=6.18, P<0.05, short-term group vs.long-term group, q=9.87, P<0.05). The hs-CRP levels in the short-term group, medium-term group and long-term group were (108.1±22.4)mg/L, (68.2±12.9)mg/L, (25.1±17.1)mg/L, respectively.The level of hs-CRP was significantly increased in the short-term group compared with the medium-term group and long-term group (short-term group vs.medium-term group, q=5.23, P<0.05, short-term group vs.long-term group, q=12.95, P<0.05). Meanwhile, PC showed higher accuracy(AUC, 0.889) than CURB-65(AUC, 0.828) and hs-CRP(AUC, 0.711) in the long-term group.The Kaplan-Meier survival function curve showed that the mortality rate was significantly higher in the high-value group compared with the low-value group(F=17.10, P<0.01). PC was an independent factor for long-term mortality and was associated with poorer survival by the COX regression analysis.@*Conclusion@#PC has a high predictive value for long-term mortality in CAP patients.
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Objective To discuss the responsibility and quality requirement of head nurses in nursing quality improvement in obstetrical and gynecological department.Methods The responsibility of head nurses in nursing quality improvement in obstetrical and gynecological department were investigated by carrying out surveys in patients of obstetrical and gynecological department.Results The quality of head nurses needed improvement and their responsibility required definitude,thus the satisfaction degree of patients and nursing quality can be improved.Conclusions Through this research,we find that the head nurses not only need good quality,but also should be given definite responsibility and certain service,supervising and management power,if so,they can fully exert their role in nursing work.